{"id":4321,"date":"2024-05-27T16:48:30","date_gmt":"2024-05-27T08:48:30","guid":{"rendered":"\/chemistry\/?p=4321"},"modified":"2026-09-20T22:27:26","modified_gmt":"2026-09-20T14:27:26","slug":"%e9%99%b3%e6%9b%9c%e9%b4%bb%e5%80%8b%e4%ba%ba%e7%b0%a1%e4%bb%8b-2","status":"publish","type":"post","link":"\/chemistry\/?p=4321","title":{"rendered":"\u9673\u66dc\u9d3b\u500b\u4eba\u7c21\u4ecb(English)"},"content":{"rendered":"\n<div class=\"wp-block-tkuwpbs5-bs5-container container chem_teach\" style=\"margin-top:var(--wp--preset--spacing--40);padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);position:relative\" block_id=\"lq3fs6oyzthhmnpj8a\"><style><\/style>\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-4 align-self-start\">\n<div class=\"wp-block-tkuwpbs5-bs5-row row\"><img decoding=\"async\" src=\"\/chemistry\/wp-content\/uploads\/2024\/01\/\u9673\u66dc\u9d3b202607-1.jpg\" class=\"img-fluid img-fluid \" alt=\"\u4e0a\u50b3\u5716\u7247\"><\/div>\n\n\n\n<p class=\"has-text-align-center\" style=\"padding-top:var(--wp--preset--spacing--30)\"><a href=\"https:\/\/teacher.tku.edu.tw\/PsnCat.aspx?t=psh_a_author_data&amp;u=t908339\" data-type=\"link\" data-id=\"https:\/\/teacher.tku.edu.tw\/PsnCat.aspx?t=psh_a_author_data&amp;u=t908339\"><i class=\"fa fa-share\" aria-hidden=\"true\"><\/i> \u6559\u5e2b\u6b77\u7a0b<\/a> <a href=\"https:\/\/teacher.tku.edu.tw\/PsnSchoolTime.aspx?u=t908339\" data-type=\"link\" data-id=\"https:\/\/teacher.tku.edu.tw\/PsnSchoolTime.aspx?u=t908339\">\u99d0\u6821\u6642\u9593<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-8 align-self-start\">\n<div class=\"wp-block-tkuwpbs5-bs5-row row teach_heading\">\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-2 align-self-start\">\n<h2 class=\"wp-block-heading\"><strong>\u9673\u66dc\u9d3b<\/strong><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-3 align-self-start\">\n<p>Professor &amp; Dean, College of Science<br>Yau-Hung Chen<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-4 align-self-start\">\n<p>TEL: (02) 2621-5656 #3009(OFFICE) <br>#3250(LAB)<br>Email : yauhung@mail.tku.edu.tw<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-3 align-self-start\">\n<p>OFFICE: C104<br>LAB: C114<\/p>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-12 align-self-start\">\n<h5 class=\"wp-block-heading\"><strong>Fields of Research<\/strong><\/h5>\n\n\n\n<p>Zebrafish Biology, Developmental Biology, Toxicology, Angiogenesis, and Cancer Biology<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Research Expertise<\/strong><\/h5>\n\n\n\n<p>Zebrafish developmental biology, with a focus on bone and skeletal muscle development.&nbsp;<br>Nephrotoxicity and reproductive toxicity assessment of xenobiotics using zebrafish models.&nbsp;<br>Identification of genetic and metabolomic biomarkers for renal diseases.&nbsp;<br>Angiogenesis and vascular biology using zebrafish and chick embryo models.&nbsp;<br>Tumor\u2013microenvironment interactions and cancer biology.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-12 align-self-start\">\n<h5 class=\"wp-block-heading\"><strong>Current Appointments<\/strong>&nbsp;<\/h5>\n\n\n\n<p>Dean, College of Science, Tamkang University&nbsp;<br>Professor, Department of Chemistry, Tamkang University&nbsp;<br>Director, Science Education Center, Tamkang University<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Academic and Administrative Appointments<\/strong><\/h5>\n\n\n\n<p><strong>2026-present<\/strong> Dean, College of Science, Tamkang University, Taiwan<br><strong>2025-present<\/strong> Director, Science Education Center, Tamkang University, Taiwan<br><strong>2019-2023<\/strong> Chair, Department of Chemistry, Tamkang University, Taiwan<br><strong>2015-2019<\/strong> Chair, Bachelor\u2019s Program in Advanced Materials Science, Tamkang University, Taiwan<br><strong>2010-present<\/strong> Professor, Department of Chemistry, Tamkang University, Taiwan<br><strong>2009-2010<\/strong> Associate Professor, Department of Chemistry, Tamkang University, Taiwan<br><strong>2007-2009<\/strong> Associate Professor, Graduate Institute of Life Science, Tamkang University, Taiwan<br><strong>2004-2007<\/strong> Assistant Professor, Graduate Institute of Life Science, Tamkang University, Taiwan<br><strong>2003-2004<\/strong> Postdoctoral Researcher, Institute of Molecular and Cellular Biology, National Taiwan University, Taiwan<br><strong>2002-2003<\/strong> Research Associate, Institute of Neuroscience, University of Oregon, Oregon, USA&nbsp;<br><strong>2001-2002<\/strong> Postdoctoral Researcher, Institute of Fisheries Science, National Taiwan University, Taiwan<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>International Research Experience and Visiting Appointments<\/strong><\/h5>\n\n\n\n<p><strong>2025<\/strong> Visiting Professor, Atomic Bomb Disease Institute, Nagasaki University, Japan (<em>JSPS International Fellow)<\/em>&nbsp;<br><strong>2019(July)<\/strong> Short-term Research Visit, University of Massachusetts Lowell, Massachusetts, USA<br><br><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-12 align-self-start\">\n<h5 class=\"wp-block-heading\"><strong>Higher Education<\/strong>&nbsp;<\/h5>\n\n\n\n<p><strong>1997\u20132001<\/strong>&nbsp;Ph.D., Institute of Fisheries Science, National Taiwan University, Taiwan&nbsp;<br><em>Research focus: Zebrafish Embryology and Developmental Biology<\/em>&nbsp;<br><strong>1995\u20131997<\/strong>&nbsp;M.S., Institute of Biochemistry, National Taiwan University, Taiwan&nbsp;&nbsp;<br><em>Research focus: Gene Regulation<\/em>&nbsp;<br><strong>1989\u20131993<\/strong>&nbsp;B.S., Department of Medical Technology, National Taiwan University, Taiwan<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h5 class=\"wp-block-heading\"><strong>Selected Publications<\/strong>&nbsp;<\/h5>\n\n\n\n<p><strong><em>Chen YH<\/em><\/strong><strong><em>*,<\/em><\/strong><em> Mohanty B, Li TS, et al. (2026).<\/em> A phenotype-driven discovery of pro-revascularization chalcone derivatives using zebrafish and CAM models. <em>Journal of Toxicology<\/em>, 2026: 6939974.&nbsp;<\/p>\n\n\n\n<p><em>Lee ASY, Lin TH, Liu YY, et al.,<\/em><strong><em> Chen YH<\/em><\/strong><strong><em>*<\/em><\/strong><em> (2025).<\/em><em> <\/em>Growth inhibition and toxicity assessments of cis-3,4-diaryl-\u03b1-methylene-\u03b3-butyrolactams in cultured human renal cancer cells and zebrafish embryos. <em>Biochimica et Biophysica Acta-General Subjects<\/em>, 1869:130761.&nbsp;<\/p>\n\n\n\n<p><em>Pan HC<\/em><em><sup>#<\/sup><\/em><em>, <\/em><strong><em>Chen YH<\/em><\/strong><strong><em><sup>#<\/sup><\/em><\/strong><strong><em>,<\/em><\/strong><em> Fang WC, Wu VC, Sun CY (2022).<\/em> Essential roles of the histone demethylase KDM4C in renal development and acute kidney injury. <em>International Journal of Molecular Sciences<\/em>, 23:9318.&nbsp;<\/p>\n\n\n\n<p><strong><em>Chen YH<\/em><\/strong><strong><em>*,<\/em><\/strong><em> Chang CY, Chang CF, et al. (2015).<\/em> Pro-angiogenic effects of chalcone derivatives in zebrafish embryos in vivo. <em>Molecules<\/em>, 20:12512\u201312524.&nbsp;<\/p>\n\n\n\n<p><strong><em>Chen YH<\/em><\/strong><strong><em>*,<\/em><\/strong><em> Chou CY, Sun CY (2015).<\/em> Impairment of cellular distribution and stability of erythropoietin receptor by direct targeting of aristolochic acid. <em>Toxicological Sciences<\/em>, 147:246\u2013254.&nbsp;<\/p>\n\n\n\n<p><strong><em>Chen YH*,<\/em><\/strong><em> Wang WH, Wang YH, Lin ZY, Wen CC, Chern CY<\/em> (2013). Evaluation of anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model. <em>Molecules<\/em>, 18:2052\u20132060.&nbsp;<\/p>\n\n\n\n<p><em>Ding YJ, <\/em><strong><em>Chen YH* <\/em><\/strong><em>(2012).<\/em><em> <\/em>Developmental nephrotoxicity of aristolochic acid in a zebrafish model. <em>Toxicology and Applied Pharmacology<\/em>, 261:59\u201365.&nbsp;<\/p>\n\n\n\n<p><strong><em>Chen YH*,<\/em><\/strong><em> Yang ZS, Wen CC, et al. (2012).<\/em> Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. <em>Food Chemistry<\/em>, 134:717\u2013724.&nbsp;<\/p>\n\n\n\n<p><em>Lee GH, Chang MY, Hsu CH, <\/em><strong><em>Chen<\/em><\/strong><strong><em><sup> <\/sup><\/em><\/strong><strong><em>YH*<\/em><\/strong> <em>(2011).<\/em> Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish. <em>Cellular and Molecular Life Sciences<\/em><em> <\/em>68: 4065-4078. <strong>(<\/strong><strong>Cover article)<\/strong>&nbsp;&nbsp;<\/p>\n\n\n\n<p><strong><em>Chen YH<\/em><\/strong><strong><em>*,<\/em><\/strong><em> Lin YT, Lee GH (2009).<\/em> Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development. <em>Bone<\/em>, 44:777\u2013784. <strong>(Cover article)<\/strong>&nbsp;<\/p>\n\n\n\n<p><em>Wang YH, Li CK, Lee GH, Tsay HJ, Tsai HJ, <\/em><strong><em>Chen YH<\/em><\/strong><strong><em>*<\/em><\/strong><strong> <\/strong>(2008). Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor axon growth disorganization. <em>Developmental Dynamics<\/em>, 237:1043\u20131050.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<p class=\"has-text-align-center view_bottom\" style=\"padding-top:var(--wp--preset--spacing--50)\"><a href=\"\/chemistry\/?page_id=148\"><button type=\"button\" class=\"btn btn-primary btn-md btn-lg\">\u8fd4\u56de\u5217\u8868\u9801<\/button><\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"wp-custom-template-common-en","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"acf":[],"_links":{"self":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/4321"}],"collection":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4321"}],"version-history":[{"count":24,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/4321\/revisions"}],"predecessor-version":[{"id":10016,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/4321\/revisions\/10016"}],"wp:attachment":[{"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4321"},{"taxonomy":"post_tag","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}